The βˢ and βᴬ alleles can be distinguished on the basis of

Question

Quizplus · Accepted Answer

The βˢ and βᴬ alleles have a single nucleotide substitution, leading to a change in the amino acid sequence of the hemoglobin beta chain. This change affects protein structure and mobility during electrophoresis, resulting in different electrophoretic mobilities of the protein products. Additionally, this single nucleotide substitution alters the length of the DNA restriction fragments, which can also be used to distinguish between the two alleles. Therefore, option E is the best choice as it includes both variations in DNA restriction fragments and different electrophoretic mobilities due to a single amino acid substitution.

The βˢ and βᴬ Alleles Can Be Distinguished on the Basis