Mutations can also occur within the regulatory regions of genes.Fragile X is an example of a disorder caused by one such mutation by increasing the length of the long arm of the X chromosome and ultimately decreasing mRNA stability.Which type of regulatory mutation causes Fragile X?

Question

Quizplus · Accepted Answer

Fragile X is caused by a mutation that involves the expansion of a triplet-repeat sequence, specifically the CGG repeat sequence in the FMR1 gene, which ultimately leads to reduced mRNA stability and the absence or reduction of the FMR1 protein. This type of mutation is not a promoter, polyadenylation, splice site, or frameshift mutation.

Mutations Can Also Occur Within the Regulatory Regions of Genes