Inherited mutations in the Xist promoter lead to defects in which epigenetic process?
A)RNAi
B)X-inactivation
C)genomic imprinting
D)position effect variegation
E)methylation of CpG islands

Question

Quizplus · Accepted Answer

Inherited mutations in the promoter region of the Xist gene can lead to defects in X-inactivation, a process in which one of the two X chromosomes in female cells is inactivated to compensate for the double dose of X-linked genes in females. The Xist gene is responsible for producing the Xist RNA that coats the inactive X chromosome and initiates the silencing of most of its genes. Mutations in the Xist promoter can disrupt the proper expression of Xist and lead to incomplete or abnormal X-inactivation.

Inherited Mutations in the Xist Promoter Lead to Defects in Which