Until recently,only apolipoprotein E (APOE)polymorphisms have been found to correlate with late-onset (nonfamilial)Alzheimer disease (AD);however,these account for less than 50% of the VG.New GWA studies have found a chromosome 12 risk locus.What method will likely be used by AD researchers going forward?
A)assessment of chromosome 12 for areas of linkage disequilibrium for AD
B)association of APOE alleles with chromosome 12 SNPs
C)sequencing of candidate genes on chromosome 12 and search for sequence similarity
D)genotyping of a large cohort of AD patients and matched controls using a microchip
E)analysis of genotypes of a large number of AD patients who have none of the expected APOE alleles

Question

Quizplus · Accepted Answer

Genotyping of a large cohort of AD patients and matched controls using a microchip is the most likely approach that AD researchers will use going forward. This method allows for the detection of genetic variations across the whole genome, rather than focusing on a specific locus or candidate genes. It also allows for the comparison of AD patients with matched controls to identify genetic variants that are more common in AD patients than in controls.

Until Recently,only Apolipoprotein E (APOE)polymorphisms Have Been Found to Correlate