According to the DSM-IV, a key distinction between substance abuse and substance dependence is that

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The DSM-IV distinguishes between substance abuse and dependence based on the presence of physical and psychological symptoms. Substance dependence involves continued use despite significant physical or psychological problems, whereas substance abuse may include repeated use in situations that are dangerous or that cause legal or social problems, but without the same degree of compulsive use. The other options (A, B, and D) are incorrect and do not capture the key distinction between substance abuse and dependence as defined by the DSM-IV.

According to the DSM-IV, a Key Distinction Between Substance Abuse