How does the ApoE4 gene appear to contribute to the development of Alzheimer's disease?

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The ApoE4 gene appears to contribute to the development of Alzheimer's disease by increasing the buildup of beta-amyloid, a protein that forms insoluble plaques in the brains of Alzheimer's patients. Research has shown that individuals with the ApoE4 gene have a higher risk of developing Alzheimer's, and that this increased risk is likely due to the gene's effect on beta-amyloid accumulation.

How Does the ApoE4 Gene Appear to Contribute to the Development