Which technique has been shown to be most successful at extending life in laboratory animals?

Question

Quizplus · Accepted Answer

Severe calorie restriction has been shown to be the most successful in extending life in laboratory animals. Many studies have demonstrated that calorie restriction can increase lifespan, delay age-related diseases, and improve overall health in a variety of species, including worms, flies, and rodents. Calorie restriction works by reducing oxidative damage and inflammation, improving mitochondrial function, and stimulating cellular repair and recycling mechanisms. The underlying mechanisms involve the activation of several longevity pathways, including sirtuins, AMPK, and mTOR. While the effects of calorie restriction on human lifespan are still unclear, some evidence suggests that it may have health benefits, such as reducing the risk of metabolic disorders, cancer, and cardiovascular disease.

Which Technique Has Been Shown to Be Most Successful at Extending