Studies have reported that which of the following creates a significant risk increase for oral cancer in individuals?

Question

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Many studies have reported a synergism between smoking and alcohol use, resulting in substantially greater risk for oral cancer in individuals who both smoke and drink heavily. Also, the chewing of betel quid and gutka, a practice that is common in Southeast Asia, is a risk factor for developing oral and pharyngeal cancer. Another risk factor is contracting an HPV infection, although only a small percentage of HPV infections develop into oropharyngeal cancer.

Studies Have Reported That Which of the Following Creates a Significant