The β chain of adult hemoglobin is composed of 146 amino acids of a known sequence.In comparing the normal β chain with the β chain in sickle cell hemoglobin,what alteration is one likely to find?

Question

Quizplus · Accepted Answer

Sickle cell hemoglobin results from a single amino acid substitution in the β chain, with valine replacing glutamic acid in the sixth position. This alteration disrupts the normal folding of hemoglobin molecules and leads to the formation of characteristic sickle-shaped red blood cells. Choices B, C, D, and E are not accurate descriptions of the genetic alteration present in sickle cell hemoglobin.

The β Chain of Adult Hemoglobin Is Composed of 146