In sporadic cases of retinoblastoma,how many gene mutations are thought to be necessary in the same cell for a tumor to develop?

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Two gene mutations are thought to be necessary in the same cell for a retinoblastoma tumor to develop. This is because retinoblastoma is caused by the inactivation of both copies of the RB1 tumor suppressor gene. If one copy is mutated or lost, the other can still function and prevent the formation of a tumor. However, when both copies are mutated or lost, there is no functioning RB1 protein to suppress tumor growth, leading to the development of retinoblastoma.

In Sporadic Cases of Retinoblastoma,how Many Gene Mutations Are Thought