Who was the first to challenge Galenic medicine in early modern Europe?

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Paracelsus was a Swiss physician who challenged Galenic medicine in the 16th century, advocating for the use of chemical remedies and rejecting the traditional theories of humoral imbalances. While Vesalius also made significant contributions to the field of medicine, his work focused more on anatomy and did not directly challenge Galen's theories. Harvey and Boyle made important discoveries in physiology and chemistry, respectively, but did not challenge Galenic medicine in the same way that Paracelsus did. Pasteur was a microbiologist who lived several centuries later and did not contribute to the early modern debate over Galenic medicine.

Who Was the First to Challenge Galenic Medicine in Early