By the Middle of the Nineteenth Century,it Seems That Science

By the middle of the nineteenth century,it seems that science had fundamentally changing humanity's position in the universe because

A) Copernicus had moved humanity from the center of the universe.
B) Newton had made the universe into a mechanism.
C) Science appeared to be saying that humanity is not the focus of God's creation.
D) Darwin's theory seemed to show that humanity is not as special as once thought.
E) all of the above