High-intensity focused ultrasound (HIFU)is a noninvasive technique used in the treatment of prostate cancer.HIFU is a targeted therapy that is highly focused into a small area without causing collateral tissue damage.Aside from primary therapy,HIFU can be used as salvage therapy,primarily after radiation.HIFU can be performed as an outpatient procedure,often with an epidural anesthetic.The HIFU-directed energy modality is best described as:

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HIFU is highly focused into a small area,creating intense heat of 80° to 100° C,which is lethal to prostate cancer tissue.HIFU destroys tissue by heat,rather than by cavitation or mechanical shearing.Since ultrasound is nonionizing,there is no collateral tissue damage.
For the majority of patients,HIFU is indicated as a curative therapy.The best candidates are clinical/pathologic stages T₁c to T₃.Because of the limited focal length of HIFU,gland volume cannot be 40 ml or larger.Aside from primary therapy,HIFU can be used as salvage therapy,primarily after radiation.HIFU can also be repeated without any increase in risk or complications.

High-Intensity Focused Ultrasound (HIFU)is a Noninvasive Technique Used in the Treatment