Small amounts of a thrombolytic drug can be instilled into portacaths and aspirated to ensure patency of the device.An example of a true statement regarding thrombolytics is:

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Intravascular thrombolytic agents are used to dissolve a thrombus so normal vascular patency can be achieved.Thrombolytic drugs activate the conversion of plasminogen to plasmin and break down fibrin.Thrombolytic drugs are most effective on a fresh clot.Thrombolytic drugs cause a systemic lytic state and hemorrhage is a possible complication.The patient should be screened for both relative and absolute contraindications for thrombolytic therapy.

Small Amounts of a Thrombolytic Drug Can Be Instilled into Portacaths