With the development of tolerance to a substance, what happens to the margin of safety?

Question

Quizplus · Accepted Answer

With the development of tolerance, the margin of safety narrows. This means that a larger amount of the substance may be needed to achieve the desired effect, but the safety range or amount that can be taken without harmful side effects does not increase at the same rate. This increases the risk of overdose, which can be dangerous or even fatal.

With the Development of Tolerance to a Substance, What Happens