A common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to the disease ____.

Question

Quizplus · Accepted Answer

The genetic variation referred to in the question is a point mutation that changes one nucleotide base in the DNA code for the beta-globin chain of hemoglobin. This change leads to a different amino acid being incorporated into the hemoglobin protein, resulting in the abnormal sickle-shaped red blood cells that cause sickle-cell anemia.

A Common Genetic Variation Which Causes a Change in the Amino