How does aspirin reduce inflammation and pain?

Question

Quizplus · Accepted Answer

Aspirin works as a nonsteroidal anti-inflammatory drug (NSAID) by inhibiting the activity of an enzyme called cyclooxygenase (COX). COX plays a key role in the production of prostaglandins, which are substances involved in pain and inflammation. By blocking COX, aspirin can decrease the levels of prostaglandins and thus alleviate pain and reduce inflammation.

Answer: D
 In addition to its COX-inhibiting effects, aspirin is also thought to reduce pain by binding to nerve receptors called TRPV1 channels. These receptors are involved in the perception of pain, heat, and other sensory stimuli. Aspirin can block the activity of TRPV1 channels, which may contribute to its analgesic (pain-relieving) properties. However, this mechanism is less well understood than the COX inhibition pathway.

How Does Aspirin Reduce Inflammation and Pain