Most likely,"host specificity" of a virus is determined by

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Quizplus · Accepted Answer

Host specificity of a virus is determined by its ability to attach to host cell receptors. This is mediated by interactions between viral attachment proteins and host cell receptors. The specificity of the interaction between the two determines the host range of the virus. Viruses that are able to recognize and bind to receptors on a particular host cell can infect and replicate within those cells, leading to the onset of infection.

Most Likely,"host Specificity" of a Virus Is Determined by