Which of these proteins could theoretically be mutated in order to create novel site specific DNA binding proteins with single strand endonuclease activity? (Select all that apply)

Question

Quizplus · Accepted Answer

Zinc finger nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs) are both engineered proteins that can be designed to target specific DNA sequences for cleavage. ZFNs use a zinc finger DNA-binding domain to recognize specific DNA sequences, while TALENs use a transcription activator-like effector domain for DNA binding. Both can be engineered to create novel site-specific DNA-binding proteins with single-strand endonuclease activity, making them useful tools for genome editing.

Which of These Proteins Could Theoretically Be Mutated in Order