An individual suffers a gentic disease whereby a protein of the complement cascade is not produced.Which protein deficiency would have the most significant adverse effect on immune health?

Question

Quizplus · Accepted Answer

Lack of C3 would have the most significant adverse effect on immune health as it is the central component of the complement cascade, leading to impaired opsonization, chemotaxis and lysis of pathogens. A deficiency in MBL surface complex, Factor B, or Factor D would lead to less severe effects as they are further downstream in the complement pathway.

An Individual Suffers a Gentic Disease Whereby a Protein of the Complement