Malaria was eradicated in the United States by 1951.This was primarily accomplished by:

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Malaria is transmitted by mosquitoes. Therefore, the most effective way to eradicate malaria is to reduce the mosquito population. This was achieved in the United States through the use of insecticides and environmental manipulation to eliminate breeding sites. Vaccines, drugs, and quarantine measures can also be effective in controlling malaria, but they alone cannot eradicate the disease.

Malaria Was Eradicated in the United States by 1951