Sulfa drug resistance involves: (Select all that apply)

Question

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Sulfa drugs work by competitively inhibiting the enzyme dihydropteroate synthase, which is involved in folate synthesis in bacteria. Resistance can develop through alteration of the enzyme's active site (A), making the drug unable to bind effectively, or through changes that affect the degree of competitive inhibition (B), such as increased production of the enzyme or the natural substrate.

Sulfa Drug Resistance Involves: (Select All That Apply)