The nurse is caring for a patient with sepsis due to necrotic tissue.The nurse knows that necrotic tissue can stimulate the inflammatory immune response.Which biochemical mediator is secreted in response to endotoxin or tissue injury?

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Tumor necrosis factor-á (TNF-á,also known as cachectin)is a polypeptide that is released from macrophages and lymphocytes in response to endotoxin,tissue injury,viral agents,and interleukins.When present in excessive amounts,TNF-á causes widespread destruction in most organ systems and is responsible for the pathophysiologic changes in systemic inflammatory response syndrome (SIRS)and septic shock,including fever,hypotension,decreased organ perfusion,and increased capillary permeability.

The Nurse Is Caring for a Patient with Sepsis Due