Which pathophysiologic event contributes to renal failure associated with tumor lysis syndrome?

Question

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When therapy is initiated,tumor cell destruction releases nucleic acids,which are metabolized into uric acid.Metabolic acidosis ensues,resulting in crystallization of the uric acid in the distal tubules of the kidneys and leading to obstruction of urine flow.Glomerular filtration rates drop as the kidneys are unable to clear the increasing amounts of uric acid.Consequently,acute kidney injury eventually occurs.

Which Pathophysiologic Event Contributes to Renal Failure Associated with Tumor