A patient has been admitted with tumor lysis syndrome (TLS).Which intervention would be incorporated into the plan of care to prevent the metabolic imbalances associated with this disorder?

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Dietary restrictions of potassium and phosphorus may be necessary.The goals in treating hyperuricemia are to inhibit uric acid formation and to increase renal clearance.These can be accomplished through the administration of sodium bicarbonate to increase the pH of the urine to above 7.0,which increases the solubility of uric acid,preventing subsequent crystallization.Administration of intravenous fluids may be necessary early in the course of treatment if inadequate hydration exists.If potassium levels rise dangerously,Kayexalate (sodium polystyrene sulfonate)may be given orally,or if the patient is unable to tolerate oral medications because of nausea and vomiting,rectal instillation may be used.

A Patient Has Been Admitted with Tumor Lysis Syndrome (TLS)