When a person with a physiological dependence on a substance needs higher and higher doses to achieve a high,that person is experiencing the characteristic signs of

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Tolerance is the characteristic sign of a physiological dependence on a substance where a person needs higher and higher doses to achieve the desired effect. This indicates a decrease in the body's response to the substance, leading to a need for more of it to achieve the desired effect.

When a Person with a Physiological Dependence on a Substance