What Does Research Have to Say About the General Effect

What does research have to say about the general effect of everyday problems and the minor nuisances of life

A)  Minor stresses produce minor effects. 
B)  Minor stresses may have significant harmful effects on both physical and mental health. 
C)  Minor stresses often have significant harmful effects on mental health, but don't affect physical health. 
D)  Minor stresses have negative effects only when coupled with major stresses.