The clinical manifestations of sickle cell anemia (SCA)are primarily the result of which physiologic alteration?
A) Decreased blood viscosity
B) Deficiency in coagulation
C) Increased red blood cell (RBC) destruction
D) Greater affinity for oxygen

Question

Quizplus · Accepted Answer

The clinical features of SCA are primarily the result of increased RBC destruction and obstruction caused by the sickle-shaped RBCs.When the sickle cells change shape,they increase the viscosity in the area where they are involved in the microcirculation.SCA does not have a coagulation deficit.Sickled red cells have decreased oxygen-carrying capacity and transform into the sickle shape in conditions of low oxygen tension.

The Clinical Manifestations of Sickle Cell Anemia (SCA)are Primarily the Result