How Do Lesioning Studies Relate to Studies of Patients with Brain

How do lesioning studies relate to studies of patients with brain injuries

A)  Lesioning was originally used for research purposes but is beginning to be accepted as a therapeutic technique. 
B)  Lesioning is an imaging method that is appropriate for use with patients who may have foreign materials lodged in their wounds. 
C)  Lesioning is used in animal research to test hypotheses generated from case studies of patients with brain damage. 
D)  Lesioning is a therapeutic technique designed to reduce symptoms associated with brain damage.