Although Various Drugs Have Various Actions and Effects Throughout the Central

Although various drugs have various actions and effects throughout the central nervous system,what effect appears to be common across virtually all abused drugs

A)  They are all deactivated in the synapse by acetylcholinesterase. 
B)  They eventually increase activity in the mesolimbic dopamine pathway, which is important for the experience of reward. 
C)  They all lead to a suppression of activity in the prefrontal cortex, which makes it more likely that an individual will become physiologically dependent. 
D)  They each have an inhibitory effect on GABA.