What Should You Expect If Laboratory Rats Have Artificially Reduced

What should you expect if laboratory rats have artificially reduced levels of insulin,based on the interaction between glucose levels and insulin levels in the body

A)  They will stop eating and lose weight. 
B)  They will show an increase in activity in the ventromedial hypothalamus. 
C)  They will stop eating, but still gain weight. 
D)  They will tend to overeat and gain weight.