Following a first mutation in a tumor suppressor gene,which of the following is commonly associated with the "second hit" in tumor generation?

Question

Quizplus · Accepted Answer

Loss of heterozygosity (LOH) is commonly associated with the second hit in tumor generation. LOH occurs when the second allele of the tumor suppressor gene is also lost or inactivated, leading to the complete loss of function of the gene. This is often the result of a chromosomal deletion or recombination event. While the other options can also contribute to tumor generation, they are not typically associated with the second hit in tumor suppressor genes.

Following a First Mutation in a Tumor Suppressor Gene,which of the Following