When does antibody diversity occur in a B cell?

Question

Quizplus · Accepted Answer

Antibody diversity occurs during B cell maturation through a process called V(D)J recombination. This process randomly shuffles and recombines gene segments that encode the variable region of the antibody, creating unique antigen-binding sites on each B cell. Once the B cell is exposed to an antigen, the antibodies it produces will be specific to that antigen due to the diverse antigen-binding sites generated during maturation. Stimulating B cells with TH1 or TH2 cells can activate them, but it does not directly affect antibody diversity. Processing and presenting antigens to B cells occurs after initial exposure and activation, so it does not occur during B cell maturation.

When Does Antibody Diversity Occur in a B Cell