Which Statements Are Accurate Regarding the Assent Process for Pediatric

Which statements are accurate regarding the assent process for pediatric research?

A) A parental signature is required for a child to participate in a study.
B) The study protocol is reviewed with the parent and not the child.
C) The child should be able to express a preference for participation.
D) A child older than age 16 does not require a parent's signature for consent.
E) The child should understand the purpose of the study.