In terms of the reduced life span and premature deaths per year in the world,the greatest risk is

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While smoking, obesity, and unsafe sex all pose significant health risks, poverty and malnutrition have a far greater impact on reducing life span and causing premature deaths worldwide. Lack of access to basic necessities such as food, clean water, and medical care can lead to a wide range of health problems and illnesses, ultimately leading to premature death. Additionally, poverty and malnutrition can exacerbate the impact of other risk factors, such as smoking or unsafe sex.

In Terms of the Reduced Life Span and Premature Deaths