Which clinical syndrome caused by gross chromosomal abnormalities is associated with bilateral cleft lip and palate, microphthalmia or anophthalmia, and polydactyly?

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Trisomy 13 is associated with bilateral cleft lip and palate, microphthalmia or anophthalmia, superficial hemangioma of the forehead or nape of the neck, growth retardation, severe mental retardation, polydactyly of the hands and feet, clenching of the fist with the thumb under the fingers, rocker-bottom feet, heart malformations, and several anomalies of the external genitals. Trisomy 21 is associated with slanted eyes. Patients are generally shorter than normal, and heart abnormalities are present in more than 30% of individuals. Intelligence level varies from near normal to marked retardation. Turner syndrome is characterized by a female phenotype. Clinically, these women are of short stature and have webbing of the neck and edema of the hands and feet. They frequently exhibit a low hairline on the nape of the neck. The chest is broad with wide-spaced nipples. The aorta is frequently abnormal, and body hair is sparse. Klinefelter syndrome is characterized by a male phenotype. These patients are taller than normal and have wide hips and a female pubic hair distribution. About 50% have gynecomastia, and intelligence levels are lower than normal in 10% of affected individuals.

Which Clinical Syndrome Caused by Gross Chromosomal Abnormalities Is Associated