Hypophosphatasia is characterized by

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Hypophosphatasia is characterized by exfoliation of teeth without evidence of periodontal or gingival disease. The basic defect in this condition is a decrease in serum alkaline phosphatase levels with increased urinary and plasma levels of phosphoethanolamine. Agenesis or abnormal formation of cementum in these patients leads to spontaneous premature shedding of primary teeth, especially mandibular incisors. The basic defect in hypophosphatasia is a decrease in serum alkaline phosphatase levels with increased urinary and plasma levels of phosphoethanolamine. Agenesis or abnormal formation of cementum rather than enamel and dentin in patients with hypophosphatasia leads to spontaneous premature shedding of primary teeth, especially mandibular incisors. The inheritance pattern of hypophosphatasia is autosomal-recessive rather than autosomal-dominant.

Hypophosphatasia Is Characterized by