Which of the following statements is true of sickle-cell anemia?

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Sickle-cell anemia is a genetic disorder that results in the production of abnormal hemoglobin, causing red blood cells to become shaped like sickles. These sickled red blood cells can block small blood vessels, decreasing the oxygen supply to tissues and causing episodes of pain and organ damage. Treatment typically involves managing the symptoms and complications, such as with pain relief and blood transfusions, but not testosterone replacement therapy. It also does not affect the ability to metabolize phenylalanine or impact height or fertility in girls.

Which of the Following Statements Is True of Sickle-Cell Anemia