To become activated,which requires being bound to a foreign antigen AND simultaneous costimulation?

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T cells require binding to a foreign antigen presented by an antigen-presenting cell (APC) and simultaneous co-stimulation to become activated. B cells also require binding to a foreign antigen, but do not require co-stimulation for activation. Interferon is a protein produced by cells during an immune response, but it does not require binding to a foreign antigen or co-stimulation for activation. MHC antigens are molecules that present foreign antigens to T cells, but they themselves do not require activation. Antigen-presenting cells, such as dendritic cells, macrophages, and B cells, present foreign antigens to T cells, but they themselves do not require activation for this process.

To Become Activated,which Requires Being Bound to a Foreign Antigen