Which of the following applies to sickle-cell trait?

Question

Quizplus · Accepted Answer

Sickling of erythrocytes occurs with severe hypoxia. While sickle-cell trait carriers are not typically symptomatic, their red blood cells can still sickle under extreme conditions of hypoxia or dehydration, particularly during strenuous exercise or high altitudes.

Answer: C 
 Painful sickling crises with multiple infarctions occur frequently. Sickle-cell disease, which is distinct from sickle-cell trait, can cause recurrent episodes of pain due to vaso-occlusive crises resulting in infarctions and subsequent organ damage.

Therefore, the best choices are B and C. Choices A and D do not apply to sickle-cell trait.

Which of the Following Applies to Sickle-Cell Trait