Which Statement Most Accurately Describes Substance Dependence

Which statement most accurately describes substance dependence?

A) It is a lack of control over use.Tolerance and withdrawal symptoms occur when intake is reduced or stopped.
B) It occurs when psychoactive drug use interferes with the work of competing neurotransmitters.
C) Symptoms occur when two or more drugs that affect the central nervous system (CNS) have additive effects.
D) It involves taking a combination of substances to weaken or inhibit the effect of another drug.