At what stage in the development of cancer do the cancerous cells grow out of control,grow their own blood vessels,and invade surrounding tissues?

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This stage is called progression, during which cancer cells acquire the ability to grow uncontrollably, form their own blood vessels (angiogenesis), and invade surrounding tissues. At this stage, the cancer is considered malignant and has the potential to metastasize to other parts of the body. Initiation and promotion are stages that precede progression; initiation involves a genetic change that can lead to the development of cancer, while promotion is the stage in which environmental factors, such as lifestyle and diet, can promote the growth of cancer cells. Metastasis is the stage in which cancer cells spread from the primary tumor to other parts of the body.

At What Stage in the Development of Cancer Do the Cancerous