The existence of chemical signaling at the synapse was first demonstrated by
A) Charles Sherrington.
B) Santiago Ramón y Cajal.
C) John Hughlings Jackson.
D) Otto Loewi.

Question

Quizplus · Accepted Answer

Otto Loewi demonstrated the existence of chemical signaling at the synapse through his experiments on frog hearts. He showed that when he stimulated the vagus nerve, it caused the release of a chemical (later identified as acetylcholine) that slowed down the heart rate. This demonstrated that neural communication can occur not just through electrical impulses, but also through chemical signals.

The Existence of Chemical Signaling at the Synapse Was First