Olney's concept of excitotoxicity suggests that most neural death in ischemia is due to
A) excess cholinergic activity.
B) insufficient gamma-aminobutyric acid (GABA) activity.
C) insufficient glutamate activity.
D) excess glutamate activity.

Question

Quizplus · Accepted Answer

Olney's concept of excitotoxicity suggests that most neuronal death in ischemia is due to excess glutamate activity. Glutamate is an excitatory neurotransmitter that is released in large amounts during ischemia, leading to overstimulation of neurons and causing an influx of calcium ions, which eventually leads to cell death.

Olney's Concept of Excitotoxicity Suggests That Most Neural Death in Ischemia