The most common initial signs and symptoms of _____ are secondary Raynaud's phenomenon, thickening and tightening of the skin of the fingers, and pain in two or more joints.

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The most common initial signs and symptoms of scleroderma are secondary Raynaud's phenomenon, thickening and tightening of the skin of the fingers, and pain in two or more joints. Anaphylaxis is a severe allergic reaction, lupus is a chronic autoimmune disease, and Sjögren's syndrome is an autoimmune disorder that primarily affects the salivary and lacrimal glands.

The Most Common Initial Signs and Symptoms of _____ Are