Patients who have heterozygous sickle cell trait have the more severe form known as sickle cell anemia.

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Patients who have heterozygous sickle cell trait (AS) carry one abnormal hemoglobin gene and one normal gene. They generally do not experience any symptoms of sickle cell disease and have a normal life expectancy. Sickle cell anemia (SS) occurs when a person inherits two abnormal hemoglobin genes, one from each parent. This results in the production of mostly abnormal hemoglobin and leads to severe symptoms of sickle cell disease.

Patients Who Have Heterozygous Sickle Cell Trait Have the More