Sickle-cell anemia is a defense against what disease?

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Sickle-cell anemia is an inherited blood disorder where the shape of the red blood cells is abnormal, causing them to stick together and block small blood vessels. It is commonly found in regions where malaria is endemic. The sickle-shaped cells are not as easily infected by the malaria parasite, providing a survival advantage to people carrying the sickle-cell trait in areas where malaria is prevalent. Therefore, sickle-cell anemia can be seen as a defense against malaria.

Sickle-Cell Anemia Is a Defense Against What Disease