What Best Describes How a Neuron Fires

What best describes how a neuron fires?

A) Na⁺ ions cross the plasma membrane initiating a wave that travels down the axon.
B) Vesicles carry neurotransmitters from the nucleus to the other end of the neuron.
C) Na⁺ ions enter one end of the neuron and diffuse to the other end down the axon.
D) Neurotransmitters enter one end of the neuron and diffuse to the other end down the axon.
E) Neurotransmitters cross the plasma membrane creating a wave that travels down the axon.