How Can Environmental Conditions Such as Salt Concentration,temperature,and PH Physically

How can environmental conditions such as salt concentration,temperature,and pH physically affect the enzyme itself?

A) Ions can bind to the active sites of enzymes,preventing the binding of substrate.
B) Changes in temperature change the rate at which molecules interact with the enzyme.
C) All these factors can disrupt the weak bonds that hold the enzyme in its active conformation.
D) These factors affect only the substrate.