During synaptic transmission,
A)the frequency of the action potential is directly correlated with neurotransmitter release.
B)the frequency of the action potential is inversely correlated with neurotransmitter release.
C)the intracellular concentration of Ca²⁺ remains stable because of intracellular buffers.
D)the concentration of Ca²⁺ is inversely related to the amount of neurotransmitter released.

Question

Quizplus · Accepted Answer

The frequency of the action potential in the presynaptic neuron is directly correlated with the amount of neurotransmitter released into the synaptic cleft. Higher frequency of action potential results in more vesicles fusing with the presynaptic membrane and releasing neurotransmitter into the synaptic cleft. This process is known as quantal release. Therefore, choice A is the correct answer. Choices B, C, and D are incorrect because they are not supported by the mechanisms of synaptic transmission.

During Synaptic Transmission